About us

Company profile

Genefron Ltd. a privately held Israeli company, specializes in the development and manufacturing of next generation, in-vitro, personalized and companion diagnostic applications, in autoimmune and acute viral infectious diseases.

The company was  established in 2011 and utilized its first 4 years of intensive R&D to achieve its first proof of concept : predicting the interferon α treatment outcome  in hepatitis C  virus patients.  The prediction accuracy reached 96% in liver biopsies.

Following this achievement Genefron has expanded its success to address chronic autoimmune diseases such as MS and RA. In addition Genefron has developed a Personalized Diagnostic Kits (PDK) used by pregnant to predict CMV transmission to fetus. All PDKs are CE marked and Israeli ministry of health approved  (read more ….)

Business Model

In Israel, Genefron is selling its RA kits through marketing company HMO’s covering approximately 70% of the total population. In addition, CMV  transmission predicting tests  are sold through a private certified lab.

Our Pipe Line

Genefron promising pipeline consists current on going clinical trials:

  • PDK for  predicting B cell depletion drugs for RA patients.
  • PDK for predicting anti TNF treatments in psoriasis arthritis and  ankylosing spondylitis.
  • In addition, Genefron is developing new signatures / products in various stages in inflammatory bowel diseases  as well as local viral disease.

The Leading Team

Mr. Yaniv Kotler (LLB, M.Sc.)
CEO & Founder
Experience:  16 year biotech entrepreneur, established biotechnology start-up (Kovax) sold it in 2018 to Phibro.  Serving in various executive roles for 25 years.

Dr. Yoav Smith (Ph.D.)
Genomic data analysis unit Management, Hebrew University – Jerusalem
Experience:  Specializing in genomic analysis, machine learning algorithms, big data analysis and bioinformatics.  Specialized in analysis of various types of biological and clinical data using advanced computing tools .

Yuval Zuk  ( B.Sc, EMBA):

Business Development

Experience: 25 Years Med-Device Industry  entrepreneur and CEO roles, Odin Medical Technologies, MRI guidance systems for neurosurgery sold to Medtronic Inc. Activiews Ltd. surgical tool guidance sold to Stryker Inc.

Orit Kotler (B.A, M.A.)

Operational Manager

Experience: 26 years in high tech/biotech, managed multi $ M projects in corporate and private companies. CEO of Kovax Ltd, sold to Phibro (2018).

Intellectual Property

The company has a firm IP which includes 1 granted (USA), 4 PCT, 1 provisional, jointly owned with Hebrew University, Israel